Bibliothèque Électronique Lac Saint-Pierre

Relationship between platelet monoamine oxidase-B (MAO-B) activity and mercury exposure in fish consumers from the Lake St. Pierre region of Que., Canada

Stamler, C. J. et Abdelouahab, N. et Vanier, C. et Mergler, D. et Chan, H. M. (2006). Relationship between platelet monoamine oxidase-B (MAO-B) activity and mercury exposure in fish consumers from the Lake St. Pierre region of Que., Canada. NeuroToxicology , 27 (3). p. 429-436. DOI: 10.1016/j.neuro.2005.12.005.

Ce document n'est pas hébergé sur Bibliothèque Électronique Lac Saint-Pierre.

Résumé

Mercury (Hg) is a widespread neurotoxic compound that bio-accumulates in fish and marine mammals. Monoamine oxidase (MAO; EC 1.4.3.4) regulates biogenic amine concentration in the brain and peripheral tissue and has been shown to be a molecular target of Hg compounds in animal models. Blood platelet monoamine oxidase-B (MAO-B) activity may reflect MAO function in the central nervous tissue. Therefore, the objective of this study was to evaluate the relationship between platelet MAO-B and Hg exposure in fish-eating adults (n = 127) living along the St. Lawrence River (Lake St. Pierre, Que., Canada). Hg concentrations were determined in blood and hair samples. A significant negative association was observed between platelet MAO-B activity and blood-Hg (r = −0.193, p = 0.029) but not with hair-Hg levels (r = −0.125, p = 0.169). Multiple linear regression analysis demonstrated that blood-Hg (β = −4.6, p = 0.011) and heavy smoking (β = −8.5, p = 0.001) were associated with reduced platelet MAO activity in the total population. In addition, this reduction in MAO-B activity appeared to be associated with blood-Hg concentrations above 3.4 μg/L (75th percentile). Possible gender related differences were also observed and are discussed. Our results suggest that MAO-B activity in blood platelets may be a useful tool to assess biochemical effects of Hg exposure in human populations. These changes in platelet MAO-B may reflect enzymatic changes in nervous tissue and should be further investigated as a surrogate marker of neurotoxicity.

Type de document: Article scientifique
Statut du texte intégral: Autre
Mots-clés libres: Surrogate biomarkers, Methylmercury, Dopamine, Serotonin, Noradrenaline, Neurotoxicity
Sujets: 4. Faune > 4.2. Poisson
4. Faune > 4.5. Mammifère
8. Impacts et monitoring > 8.1. Qualité de l’eau
Date de dépôt: 23 août 2016 00:31
Dernière modification: 04 sept. 2016 14:00
URI: http://belsp.uqtr.ca/id/eprint/529

Actions (Identification requise)

Dernière vérification avant le dépôt Dernière vérification avant le dépôt
Coopérative de solidarité de la Réserve de la biosphère du Lac-Saint-Pierre
Concepteur de la BELSP : André Barabé, Ph. D.