Stamler, C. J. et Abdelouahab, N. et Vanier, C. et Mergler, D. et Chan, H. M. (2006). Relationship between platelet monoamine oxidase-B (MAO-B) activity and mercury exposure in fish consumers from the Lake St. Pierre region of Que., Canada. NeuroToxicology , 27 (3). pp. 429-436. DOI: 10.1016/j.neuro.2005.12.005.
Ce document n'est pas hébergé sur Bibliothèque Électronique Lac Saint-Pierre.Résumé
Mercury (Hg) is a widespread neurotoxic compound that bio-accumulates in fish and marine mammals. Monoamine oxidase (MAO; EC 1.4.3.4) regulates biogenic amine concentration in the brain and peripheral tissue and has been shown to be a molecular target of Hg compounds in animal models. Blood platelet monoamine oxidase-B (MAO-B) activity may reflect MAO function in the central nervous tissue. Therefore, the objective of this study was to evaluate the relationship between platelet MAO-B and Hg exposure in fish-eating adults (n = 127) living along the St. Lawrence River (Lake St. Pierre, Que., Canada). Hg concentrations were determined in blood and hair samples. A significant negative association was observed between platelet MAO-B activity and blood-Hg (r = −0.193, p = 0.029) but not with hair-Hg levels (r = −0.125, p = 0.169). Multiple linear regression analysis demonstrated that blood-Hg (β = −4.6, p = 0.011) and heavy smoking (β = −8.5, p = 0.001) were associated with reduced platelet MAO activity in the total population. In addition, this reduction in MAO-B activity appeared to be associated with blood-Hg concentrations above 3.4 μg/L (75th percentile). Possible gender related differences were also observed and are discussed. Our results suggest that MAO-B activity in blood platelets may be a useful tool to assess biochemical effects of Hg exposure in human populations. These changes in platelet MAO-B may reflect enzymatic changes in nervous tissue and should be further investigated as a surrogate marker of neurotoxicity.
| Type de document: | Article scientifique |
|---|---|
| Statut du texte intégral: | Autre |
| Mots-clés libres: | Surrogate biomarkers, Methylmercury, Dopamine, Serotonin, Noradrenaline, Neurotoxicity |
| Sujets: | 4. Faune > 4.2. Poisson 4. Faune > 4.5. Mammifère 8. Impacts et monitoring > 8.1. Qualité de l’eau |
| Date de dépôt: | 23 août 2016 00:31 |
| Dernière modification: | 04 sept. 2016 14:00 |
| URI: | https://belsp.uqtr.ca/id/eprint/529 |
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