Boily, M. et Thibodeau, J. et Bisson, M. (2009). Retinoid metabolism (LRAT, REH) in the liver and plasma retinoids of bullfrog, Rana catesbeiana, in relation to agricultural contamination. Aquatic Toxicology , 91 . pp. 118-125. DOI: 10.1016/j.aquatox.2008.11.006.
Ce document n'est pas hébergé sur Bibliothèque Électronique Lac Saint-Pierre.Résumé
Retinoids have been extensively studied in birds, fish and mammals where their imbalances are associated with adverse effects on growth and reproduction along with decreased embryo survival and deformities. Organochlorine compounds may alter the retinoid system but little is known about the effects of agricultural contaminants on their metabolism. In the Yamaska River project, the retinoid system in bullfrogs is monitored to investigate the possible impact of agricultural contaminants on retinoid homeostasis. Retinoids were measured in liver and plasma of male bullfrogs collected from six locations subject to increasing agricultural activity in the Yamaska River watershed. Bullfrogs living in medium and high agricultural activity areas demonstrated lower hepatic retinyl palmitate and higher hepatic retinol levels when compared to frogs associated with low contaminated sites. Changes in the concentration of hepatic esters could be related to an altered activity of REH or LRAT, enzymes respectively linked to the hydrolysis of retinyl palmitate and the esterification of retinol. A partial characterization and the analysis of liver microsomial REH and LRAT showed significantly higher hydrolysis and lower esterification activities in highly contaminated sites. Enzymatic activities seemed to be influenced by plasma DROH but not by plasma retinol. Bullfrogs from the most contaminated sites showed altered retinoic metabolism that should increase concern for frogs living in intensive agricultural areas.
| Type de document: | Article scientifique |
|---|---|
| Courriel: | boily.monique@uqam.ca, NON SPÉCIFIÉ, NON SPÉCIFIÉ |
| Statut du texte intégral: | Autre |
| Mots-clés libres: | Frog, Retinoids, REH, LRAT, Agricultural contaminants, Yamaska River |
| Sujets: | 4. Faune > 4.3. Amphibien 6. Milieu humain > 6.2. Agriculture |
| Date de dépôt: | 24 sept. 2016 13:54 |
| Dernière modification: | 10 nov. 2016 16:44 |
| URI: | https://belsp.uqtr.ca/id/eprint/594 |
Gestion Actions (Identification requise)
 |
Dernière vérification avant le dépôt |
